The elimination of hepatitis D as a public health problem: Needs and challenges

Author:

Vanwolleghem Thomas123ORCID,Armstrong Paige A.34,Buti Maria35,FitzSimons David36,Valckx Sara3,Hendrickx Greet3,Van Damme Pierre3

Affiliation:

1. Laboratory for Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium

2. Universitair Ziekenhuis Antwerpen Edegem Belgium

3. Viral Hepatitis Prevention Board, Centre for the Evaluation of Vaccination (CEV), VAXINFECTIO University of Antwerp Antwerp Belgium

4. Division of Viral Hepatitis US Centers for Disease Control and Prevention (CDC) Atlanta Georgia USA

5. Hospital General Universitari Valle Hebron Barcelona Spain

6. Independent Researcher London UK

Abstract

AbstractInfection with hepatitis D virus leads to liver disease and cancer most rapidly of all hepatitis viruses. However, knowledge about hepatitis D remains poor and the burden and impact are underestimated, even though some 12–15 million people mainly in low‐ and middle‐income countries may be affected. Its epidemiology is changing, with increasing migration leading to increased risks of infection and disease. A recent Viral Hepatitis Prevention Board meeting reviewed the current epidemiological status, improvements in diagnostic testing, advances in the development of novel antiviral agents in phase III trials and the need for a greater public health response, such as new guidelines and recommended testing of all people newly identified as infected with hepatitis B virus for hepatitis D virus infection. It identified issues and needs for attention with regard to prevention, diagnosis and treatment.

Publisher

Wiley

Subject

Virology,Infectious Diseases,Hepatology

Reference21 articles.

1. Viral Hepatitis Prevention Board.VHPB technical meeting: the changing context of hepatitis Delta.2021October Online VHPB meetings | Viral Hepatitis Prevention Board.https://www.vhpb.org/node/270 Accessed February 15 2023.

2. Seventy‐fifth World Health Assembly resolution WHA75.20.2022.https://apps.who.int/gb/ebwha/pdf_files/WHA75/A75_R20‐en.pdf Accessed February 15 2023.

3. World Health Organization.Global health sector strategies on respectively HIV viral hepatitis and sexually transmitted infections for the period 2022–2030.https://apps.who.int/iris/handle/10665/360348 Accessed 17/02/2023.

4. Hepatitis D Virus Coinfection and Superinfection

5. Hepatitis B virus/hepatitis D virus epidemiology: Changes over time and possible future influence of the SARS-CoV-2 pandemic

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