Use of levothyroxine for euthyroid, thyroid antibody positive women with infertility: Analyses of aggregate data from a survey of European thyroid specialists (Treatment of Hypothyroidism in Europe by Specialists: An International Survey)-Reference-Cited by-同舟云学术

Use of levothyroxine for euthyroid, thyroid antibody positive women with infertility: Analyses of aggregate data from a survey of European thyroid specialists (Treatment of Hypothyroidism in Europe by Specialists: An International Survey)

Published:2024-06-10 Issue:2 Volume:101 Page:180-190
ISSN:0300-0664
Container-title:Clinical Endocrinology
language:en
Short-container-title:Clinical Endocrinology

Author:

Negro Roberto¹^ORCID,Žarković Miloš²^ORCID,Attanasio Roberto³^ORCID,Hegedüs Laszlo⁴^ORCID,Nagy Endre V.⁵^ORCID,Papini Enrico⁶^ORCID,Akarsu Ersin⁷^ORCID,Alevizaki Maria⁸^ORCID,Ayvaz Göksun⁹^ORCID,Bednarczuk Tomasz¹⁰^ORCID,Beleslin Biljana Nedeljković²^ORCID,Berta Eszter⁵^ORCID,Bodor Miklos⁵^ORCID,Borissova Anna Maria¹¹^ORCID,Boyanov Mihail¹²^ORCID,Buffet Camille¹³^ORCID,Burlacu Maria‐Cristina¹⁴^ORCID,Ćirić Jamina²^ORCID,Cohen Chagit Adler¹⁵,Díez Juan J.¹⁶¹⁷¹⁸^ORCID,Dobnig Harald¹⁹^ORCID,Fadeyev Valentin²⁰^ORCID,Field Benjamin C. T.²¹^ORCID,Fliers Eric²²^ORCID,Führer Dagmar²³^ORCID,Galofré Juan C.²⁴^ORCID,Hakala Tommi²⁵^ORCID,Jan Jiskra²⁶^ORCID,Kopp Peter²⁷^ORCID,Krebs Michael²⁸^ORCID,Kršek Michal²⁶^ORCID,Kužma Martin²⁹^ORCID,Leenhardt Laurence¹³^ORCID,Luchytskiy Vitaliy³⁰^ORCID,Puga Francisca Marques³¹^ORCID,McGowan Anne³²^ORCID,Melo Miguel³³^ORCID,Metso Saara³⁴^ORCID,Moran Carla³⁵³⁶³⁷^ORCID,Morgunova Tatyana²⁰^ORCID,Niculescu Dan Alexandru³⁸^ORCID,Perić Božidar³⁹^ORCID,Planck Tereza⁴⁰^ORCID,Poiana Catalina³⁸^ORCID,Robenshtok Eyal⁴¹^ORCID,Rosselet Patrick Olivier⁴²^ORCID,Ruchala Marek⁴³^ORCID,Riis Kamilla Ryom⁴^ORCID,Shepelkevich Alla⁴⁴^ORCID,Tronko Mykola⁴⁵^ORCID,Unuane David⁴⁶^ORCID,Vardarli Irfan⁴⁷⁴⁸^ORCID,Visser Edward⁴⁹^ORCID,Vryonidou Andromachi⁵⁰^ORCID,Younes Younes R.⁵¹^ORCID,Perros Petros⁵²^ORCID

Affiliation:

1. Division of Endocrinology, Presidio Ospedaliero “V. Fazzi Lecce Italy

2. Faculty of Medicine University of Belgrade Belgrade Serbia

3. Scientific Committee, Associazione Medici Endocrinologi Milan Italy

4. Department of Endocrinology Odense University Hospital Odense Denmark

5. Department of Medicine, Division of Endocrinology, Faculty of Medicine University of Debrecen Debrecen Hungary

6. Department of Endocrinology and Metabolism Regina Apostolorum Hospital Albano Laziale Rome Italy

7. Department of Internal Medicine, Division of Endocrinology, Faculty of Medicine Gaziantep University Gaziantep Turkey

8. Department of Clinical Therapeutics, School of Medicine, Endocrine Unit and Diabetes Centre, Alexandra Hospital National and Kapodistrian University of Athens Athens Greece

9. Department of Endocrinology and Metabolism Koru Ankara Hospital Ankara Turkey

10. Department of Internal Medicine and Endocrinology Medical University of Warsaw Warsaw Poland

11. Clinic of Endocrinology and Metabolism, Medical Faculty, University Hospital “Sofiamed” Sofia University “Saint Kliment Ohridski” Sofia Bulgaria

12. Department of Internal Medicine, Clinic of Endocrinology and Metabolism, University Hospital “Alexandrovska” Medical University Sofia Sofia Bulgaria

13. Thyroid Diseases and Endocrine Tumor Department, GRC 16 Thyroid Tumors, APHP, Hôpital Pitié‐Salpêtriére Sorbonne University Paris France

14. Department of Endocrinology and Nutrition Université Catholique de Louvain Brussels Belgium

15. Rabin Medical Center Hasharon Campus Petach Tikva Israel

16. Department of Endocrinology Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain

17. Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana Majadahonda Spain

18. Department of Medicine Universidad Autónoma de Madrid Madrid Spain

19. Thyroid and Osteoporosis Praxis, Kumberg, Austria, Thyroid Practice for Radiofrequency Ablation Vienna Austria

20. Department of Endocrinology No. 1, N.V. Sklifosovsky Institute of Clinical Medicine I.M. Sechenov 1st Moscow State Medical University Moscow Russian Federation

21. Section of Clinical Medicine, Faculty of Health & Medical Sciences University of Surrey Guildford Surrey UK

22. Department of Endocrinology & Metabolism, Amsterdam UMC University of Amsterdam Amsterdam The Netherlands

23. Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen University‐Duisburg‐Essen Essen Germany

24. Department of Endocrinology Clínica Universidad de Navarra, Pamplona, Spain, Instituto de Investigación Sanitaria de Navarra Pamplona Spain

25. Department of Surgery Tampere University Hospital Tampere Finland

26. 3rd Department of Medicine, 1st Faculty of Medicine, General University Hospital Charles University Prague Czech Republic

27. Division of Endocrinology, Diabetes and Metabolism University of Lausanne Lausanne Switzerland

28. Internal Medicine III, Division of Endocrinology and Metabolism Medical University of Vienna Vienna Austria

29. 5th Department of Internal Medicine Medical Faculty of Comenius University and University Hospital Bratislava Slovakia

30. Department of Reproductive Endocrinology Institute of Endocrinology and Metabolism V.P. Komissarenko, National Academy of Medical Science of Ukraine Kyiv Ukraine

31. Endocrinology, Diabetes and Metabolism Service, Centro Hospitalar Universitário de Santo António Porto Portugal

32. Robert Graves Institute, Tallaght University Hospital Dublin Ireland

33. Department of Endocrinology, Diabetes and Metabolism, Medical Faculty University of Coimbra Coimbra Portugal

34. Department of Endocrinology Tampere University Hospital Tampere Finland

35. Diabetes & Endocrinology Section, Beacon Hospital Dublin Ireland

36. Endocrine Department St Vincent's University Hospital Dublin Ireland

37. School of Medicine, University College Dublin Dublin Ireland

38. Department of Endocrinology Carol Davila University of Medicine and Pharmacy Bucharest Romania

39. Department of Endocrinology, Diabetes and Metabolic Diseases “Mladen Sekso” University Hospital Center “Sisters of Mercy” Zagreb Croatia

40. Department of Endocrinology Skåne University Hospital Malmö Sweden

41. Endocrinology and Metabolism Institute and Davidoff Center, Rabin Medical Center, Faculty of Medicine Tel Aviv University Petah Tikva Israel

42. Cabinet Médical 2, rue Bellefontaine Lausanne Switzerland

43. Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznań Poland

44. Department of Endocrinology Belarusian State Medical University Minsk Republic of Belarus

45. Institute of Endocrinology and Metabolism V.P. Komisarenko, National Academy of Medical Sciences of Ukraine Kyiv Ukraine

46. Department of Internal Medicine Endocrine Unit Brussel Belgium

47. Department of Medicine I, Klinikum Vest GmbH, Knappschaftskrankenhaus Recklinghausen, Academic Teaching Hospital Ruhr‐University Bochum Mannheim Germany

48. 5th Medical Department, Division of Endocrinology and Diabetes, Medical Faculty Mannheim Heidelberg University Mannheim Germany

49. Department of Internal Medicine Rotterdam Thyroid Center, Erasmus Medical Center Rotterdam The Netherlands

50. Department of Endocrinology Diabetes Centre, Hellenic Red Cross Hospital Athens Greece

51. East Surrey Hospital, Surrey & Sussex Healthcare NHS Trust Redhill Surrey UK

52. Institute of Translational and Clinical Research Newcastle University Newcastle upon Tyne UK

Abstract

AbstractObjectivesThe use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb) is not supported by the available evidence. The aim of the study was to document the use of LT4 by European thyroid specialists in such patients.DesignThe data presented derive from Treatment of Hypothyroidism in Europe by Specialists, an International Survey (THESIS), a questionnaire conducted between 2019 and 2021 to document the management of hypothyroidism by European thyroid specialists. Here, we report the aggregate results on the use of LT4 in infertile, euthyroid women with positive TPOAb.ResultsA total of 2316/5406 (42.8%) respondents stated that LT4 may be indicated in TPOAb positive euthyroid women with infertility. The proportion of those replying positively to this question varied widely across different countries (median 39.4, range 22.9%–83.7%). In multivariate analyses males (OR: 0.8; CI: 0.7–0.9) and respondents >60 years (OR: 0.7; 0.6–0.8) were the least inclined to consider LT4 for this indication. Conversely, respondents managing many thyroid patients (“weekly” [OR: 1.4; CI: 1.0–1.9], “daily” [OR: 1.8; CI: 1.3–2.4]) and practicing in Eastern Europe (OR: 1.5; CI: 1.3–1.9) were most likely to consider LT4.ConclusionsA remarkably high number of respondents surveyed between 2019 and 2021, would consider LT4 treatment in TPOAb positive euthyroid women with infertility. This view varied widely across countries and correlated with sex, age and workload, potentially influencing patient management. These results raise concerns about potential risks of overtreatment.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.15099

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