In vitro susceptibility testing of tetracycline‐class antibiotics against slowly growing non‐tuberculous mycobacteria

Author:

Li Anqi12ORCID,Tan Zhili12,He Siyuan12,Chu Haiqing123

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China

2. School of Medicine Tongji University Shanghai China

3. Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China

Abstract

AbstractNon‐tuberculous mycobacterial infections are gradually increasing worldwide, with slow‐growing mycobacteria such as Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii accounting for the majority of cases. The use of tetracyclines has received renewed attention in recent years, and this study was designed to investigate the antibacterial activity of omadacycline, eravacycline, tigecycline, sarecycline, minocycline and doxycycline against M. avium, M. intracellulare and M. kansasii. Susceptibility testing of six tetracyclines was conducted against M. avium, M. intracellulare and M. kansasii isolates, and all the clinical isolates were collected from January 2012 to December 2018. All six agents exhibited poor antibacterial activity against slowly growing mycobacteria (SGM) isolates of three subspecies with MIC50 and MIC90 ≥8 μg/mL. M. intracellulare and M. kansasii had lower resistance rates to omadacycline than the other five drugs. The severe resistance of SGM to tetracycline suggests that developing tetracycline‐class antibiotics needs to overcome existing resistance mechanisms.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

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