The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways-Reference-Cited by-同舟云学术

The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways

Published:2017-01-24 Issue:2 Volume:44 Page:222-234
ISSN:0305-1870
Container-title:Clinical and Experimental Pharmacology and Physiology
language:en
Short-container-title:Clin Exp Pharmacol Physiol

Author:

Tsubaki Masanobu¹,Fujiwara Daichiro¹²,Takeda Tomoya¹,Kino Toshiki¹,Tomonari Yoshika¹,Itoh Tatsuki³,Imano Motohiro⁴,Satou Takao⁵,Sakaguchi Katsuhiko²,Nishida Shozo¹

Affiliation:

1. Division of Pharmacotherapy; Kindai University School of Pharmacy; Kowakae Higashi-Osaka Japan

2. Department of Pharmacy; Japanese Red Cross Society Wakayama Medical Center; Wakayama Japan

3. Department of Food Science and Nutrition; Kindai University School of Agriculture; Nara Nara Japan

4. Department of Surgery; Kindai University School of Medicine; Osakasayama Osaka Japan

5. Department of Pathology; Kindai University School of Medicine; Osakasayama Osaka Japan

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Strategic Research Foundation at Private Universities

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/1440-1681.12690/fullpdf

Reference41 articles.

1. Potential molecular prognostic markers in head and neck squamous cell carcinomas;Quon;Head Neck,2001

2. Genetic mechanisms in squamous cell carcinoma of the head and neck;Jefferies;Oral Oncol,2001

3. Head and neck cancer;Vokes;N Engl J Med,1993

4. Molecular therapy in head and neck oncology;Bernier;Nat Rev Clin Oncol,2009

5. Ras oncogenes in human cancer: a review;Bos;Cancer Res,1989

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