Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig

Author:

Edge Deirdre1,Shortt Christine M2,Gobbo Oliviero L3,Teughels Stephanie4,Prina-Mello Adriele56,Volkov Yuri56,MacEneaney Peter7,Radomski Marek W3,Markos Farouk2

Affiliation:

1. Department of Physiology; School of Medicine; Trinity Biomedical Sciences Institute; Trinity College Dublin; Ireland

2. Department of Physiology; University College Cork; Cork Ireland

3. School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute; Dublin Ireland

4. PEPRIC nv; Leuven Belgium

5. School of Medicine; Trinity College Dublin; Dublin Ireland

6. CRANN; Trinity College Dublin; Dublin Ireland

7. Mercy University Hospital; Dublin Ireland

Funder

European Community's Seventh Framework Program

Multifunctional Nanoparticles for the Selective Detection and Treatment of Cancer (MULTIFUN)

Strategic Research Fund

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Reference24 articles.

1. Globocan Estimated Cancer Incidence, Mortalitly and Prevelance Worldwide in 2012 World Health Organization 2012 http://www.ncri.ie/news/article/iarc-release-globocan-2012-global-cancer-burden-rises-141-million-new-cases-2012-and

2. Nanoparticle and targeted systems for cancer therapy;Brannon-Peppas;Adv. Drug Deliv. Rev.,2004

3. Biological applications of magnetic nanoparticles;Colombo;Chem. Soc. Rev.,2012

4. Iron oxide-based nanostructures for MRI and magnetic hyperthermia;Hilger;Nanomedicine (Lond.),2012

5. Superparamagnetic iron oxide polyacrylic acid coated gamma-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice;Iversen;Toxicol. Appl. Pharmacol.,2013

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