αB-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca2+-handling proteins and endoplasmic reticulum stress in mice

Author:

Jiao Qibin123,Sanbe Atsushi4,Zhang Xingwei1,Liu Jun-Ping1,Minamisawa Susumu23

Affiliation:

1. Department of Cardiology; The Affiliated Hospital of Hangzhou Normal University; Institute of Ageing Research; School of Medicine; Hangzhou Normal University; Hangzhou China

2. Department of Life Science and Medical Bio-Science; Waseda University; Tokyo Japan

3. Department of Cell Physiology; Jikei University; Tokyo Japan

4. Department of Pharmacotherapeutics; School of Pharmacy; Iwate Medical University; Iwate Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology of Japan

MEXT

MEXT-Supported Program for the Strategic Research Foundation at Private Universities

Nakatomi Foundation

Honjo International Scholarship Foundation

Sumitomo Mitsui Trust Bank Circulation

Japan Medical Association

Japan Society for the Promotion of Science

Zhejiang Provincial Natural Science Foundation of China

Hangzhou City Science and Technology Commission

Zhejiang Provincial Medical Science and Technology

Scientific Research Foundation of Education Department of Zhejiang Province, China

National Basic Research Program of China

Publisher

Wiley

Subject

Physiology (medical),Pharmacology,Physiology

Reference50 articles.

1. Human alpha B-crystallin (CRYA2) gene mapped to chromosome 11q12-q23;Brakenhoff;Hum. Genet.,1990

2. Human alpha B-crystallin gene and preferential promoter function in lens;Dubin;Genomics,1990

3. Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin;Perng;J. Cell Sci.,1999

4. The function of alpha-crystallin in vision;Horwitz;Semin. Cell Dev. Biol.,2000

5. Binding of the stress protein alpha B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo;Golenhofen;J. Mol. Cell. Cardiol.,1999

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