Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs

Author:

Michaud Veronique12,Dow Pamela1,Al Rihani Sweilem B.1,Deodhar Malavika1,Arwood Meghan1,Cicali Brian3,Turgeon Jacques12

Affiliation:

1. Tabula Rasa HealthCare Precision Pharmacotherapy Research & Development Institute Orlando Florida USA

2. Faculty of Pharmacy Université de Montréal Montreal Quebec Canada

3. College of Pharmacy Lake Nona Campus University of Florida Orlando Florida USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference50 articles.

1. US National Library of Medicine.ClinicalTrials.gov.COVID‐19.. Accessed August 13 2020.

2. Al Rihani S.B.et al.Potential COVID‐19 treatment options (Off‐label).. Accessed August 13 2020.

3. Simpson T. Kovacs R.J.&Stecker E.C.Ventricular arrhythmia risk due to hydroxychloroquine‐azithromycin treatment for COVID‐19. (2020).

4. Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells

5. Conduction disorder and QT prolongation secondary to long-term treatment with chloroquine

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