Affiliation:
1. Department of Gastroenterology The Third Xiangya Hospital, Central South University Changsha China
2. Centre for Global Health Zhejiang University School of Medicine Hangzhou China
3. Department of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China
4. Unit of Cardiovascular and Nutritional Epidemiology Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden
5. Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division University of Oxford, John Radcliffe Hospital Oxford UK
6. Unit of Medical Epidemiology, Department of Surgical Sciences Uppsala University Uppsala Sweden
7. Centre for Global Health Usher Institute, University of Edinburgh Edinburgh UK
8. Cancer Research UK Edinburgh Centre Medical Research Council Institute of Genetics and Cancer, University of Edinburgh Edinburgh UK
Abstract
SummaryBackgroundEvidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causal associations of circulating levels of antioxidants, minerals and vitamins with CD and UC.MethodsSingle‐nucleotide polymorphisms associated with antioxidants (beta‐carotene, lycopene and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc and selenium), and vitamins (folate, vitamins A, B6, B12, C, D, E and K1) were employed as instrumental variables. Genetic associations with CD and UC were extracted from the UK Biobank, the FinnGen study and the International Inflammatory Bowel Disease Genetics Consortium. The inverse variance weighted method and sensitivity analyses were performed.ResultsGenetically predicted higher lycopene (OR = 0.94, 95% CI: 0.91–0.97), vitamins D (OR = 0.65, 95% CI: 0.54–0.79) and K1 (OR = 0.93, 95% CI: 0.90–0.97) levels were inversely associated with CD risk, whereas genetically predicted higher magnesium (OR = 1.53, 95% CI: 1.23–1.90) levels were positively associated with CD risk. Higher levels of genetically predicted lycopene (OR = 0.91, 95% CI: 0.88–0.95), phosphorus (OR = 0.69, 95% CI: 0.58–0.82), selenium (OR = 0.91, 95% CI: 0.85–0.97), zinc (OR = 0.91, 95% CI: 0.89–0.94), folate (OR = 0.71, 95% CI: 0.56–0.92) and vitamin E (OR = 0.78, 95% CI: 0.69–0.88) were associated with reduced UC risk, whereas genetically predicted high levels of calcium (OR = 1.46, 95% CI: 1.22–1.76) and magnesium (OR = 1.24, 95% CI: 1.03–1.49) were associated with increased risk of UC.ConclusionsOur study provided evidence that circulating levels of antioxidants, minerals and vitamins might be causally linked to the development of IBD.
Funder
National Natural Science Foundation of China
Science Fund for Distinguished Young Scholars of Zhejiang Province
Cancerfonden
Vetenskapsrådet
Key Project of Research and Development Plan of Hunan Province
Subject
Pharmacology (medical),Gastroenterology,Hepatology