Neurobiological correlation between phosphorylated tau and mood symptoms in memory clinic patients

Author:

Ozaki Takashi1ORCID,Hashimoto Naoki1ORCID,Udo Niki1ORCID,Narita Hisashi1ORCID,Nakagawa Shin2,Kusumi Ichiro1

Affiliation:

1. Department of Psychiatry, Graduate School of Medicine Hokkaido University Sapporo Japan

2. Division of Neuropsychiatry, Department of Neuroscience, Graduate School of Medicine Yamaguchi University Ube Japan

Abstract

BackgroundAlzheimer's disease (AD) dementia and mild cognitive impairment are characterised by impaired cognition accompanied by neuropsychiatric symptoms (NPS) relating to mood, including depression, anxiety, and apathy. However, the utility of AD biomarkers for predicting mood symptoms of NPS remains controversial. Herein, we analyzed the relationship between phosphorylated tau (p‐tau) and depression, anxiety, and apathy of NPS. We also examined the influence of genetic factors such as apolipoprotein E (APOE) ε4 on these relationships.MethodsWe conducted a cross‐sectional survey in older patients (n = 122) with normal cognition (n = 12), mild cognitive impairment (n = 46), and AD (n = 64) strictly diagnosed by the board of psychiatrists and neurologists of Hokkaido University. NPS of the patients were assessed using the Neuropsychiatric Inventory Questionnaire (NPI). All patients also received a lumbar puncture to obtain cerebral spinal fluid for assessment of p‐tau. The inverse probability weighting method was used to adjust for demographic differences between the p‐tau present group and the p‐tau absent group.ResultsThere was an association between p‐tau accumulation and decreased incidence of depression and apathy. APOE ε4 non‐carriers also showed a trend toward a negative association between p‐tau and depression, which was not evident in APOE ε4 carriers.ConclusionsWe provide new evidence for a negative correlation between p‐tau and depression and apathy of NPS, which may be influenced by APOE ε4. Future longitudinal studies are required to confirm the utility of p‐tau for predicting the course of mood symptoms in patients with cognitive decline.

Funder

Asahi Kasei Pharma Corporation

Astellas Pharma

Boehringer Ingelheim

Daiichi Sankyo Company

Dainippon Sumitomo Pharma

Eisai

Eli Lilly Japan

Janssen Pharmaceuticals

Kyowa Kirin Pharmaceutical Development

H. Lundbeck A/S

Meiji Seika Pharma

Mitsubishi Tanabe Pharma Corporation

Mochida Pharmaceutical Company

Merck Sharp and Dohme

Mylan

Novartis Pharma

Otsuka Pharmaceutical

Pfizer

Shionogi

Takeda Pharmaceutical Company

Tsumura and Company

Yoshitomiyakuhin Corporation

Publisher

Wiley

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Gerontology

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