The relationship between vitamin D deficiency and diabetic foot ulcer: A meta‐analysis

Author:

Li Xin1,Kou Shaojie2,Chen Guo3,Zhao Bingjie4,Xue Jingdong2,Ding Rui1,Zhao Xiaoyan1,Ye Miaoqing2,Yang Yueqing2,Yue Rensong1,Li Fenping2ORCID

Affiliation:

1. Department of Endocrinology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China

2. Department of Liver Disease Shaanxi Provincial Hospital of Traditional Chinese Medicine Xi'an China

3. Department of Infectious Diseases Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China

4. Department of Haematology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China

Abstract

AbstractA meta‐analysis investigation to measure the relationship between vitamin D deficiency (VDD) and diabetic foot ulcer (DFU). A comprehensive literature inspection till February 2023 was applied and 1765 interrelated investigations were reviewed. The 15 chosen investigations enclosed 2648 individuals with diabetes mellitus in the chosen investigations' starting point, 1413 of them were with DFUs, and 1235 were without DFUs. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to compute the value of the relationship between VDD and DFU by the dichotomous and continuous approaches and a fixed or random model. Individuals with DFUs had significantly lower vitamin D levels (VDL) (MD, −7.14; 95% CI, −8.83 to −5.44, P < 0.001) compared to those without DFU individuals. Individuals with DFUs had a significantly higher number of VDD individuals (OR, 2.27; 95% CI, 1.63‐3.16, P < 0.001) compared to those without DFU individuals. Individuals with DFU had significantly lower VDL and a significantly higher number of VDD individuals compared to those without DFU individuals. However, caused of the small sample sizes of several chosen investigations for this meta‐analysis, care must be exercised when dealing with its values.

Publisher

Wiley

Subject

Dermatology,Surgery

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