DNA-histone complexes as ligands amplify cell penetration and nuclear targeting of anti-DNA antibodies via energy-independent mechanisms

Author:

Zannikou Markella1,Bellou Sofia23,Eliades Petros1,Hatzioannou Aikaterini1,Mantzaris Michael D.4,Carayanniotis George5,Avrameas Stratis1,Lymberi Peggy1ORCID

Affiliation:

1. Immunology Laboratory; Immunology Department; Hellenic Pasteur Institute; Athens Greece

2. Division of Biomedical Research; Foundation of Research and Technology-Hellas; Institute of Molecular Biology & Biotechnology; University Campus; Ioannina Greece

3. Department of Informatics and Telecommunications Engineering; University of Western Macedonia; Kozani Greece

4. Laboratory of Biological Chemistry; Medical School; University of Ioannina; Ioannina Greece

5. Division of Endocrinology; Faculty of Medicine; Memorial University of Newfoundland; St John's NL Canada

Funder

Hellenic General Secretariat for Research and Technology (Ministry of Education, Lifelong Learning and Religious Affairs)

Bodossaki Foundation

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference60 articles.

1. Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus;Bavel;Arthritis Rheum,2008

2. Nucleosome-specific antibody from an autoimmune MRL/Mp-lpr/lpr mouse;Losman;Arthritis Rheum,1993

3. Antibody penetration into living cells. III. Effect of antiribonucleoprotein IgG on the cell cycle of human peripheral blood mononuclear cells;Alarcon-Segovia;Clin Immunol Immunopathol,1982

4. Penetration of autoantibodies into living epithelial cells;Golan;J Invest Dermatol,1993

5. Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo;Vlahakos;J Am Soc Nephrol,1992

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