Potential of myricetin to restore the immune balance in dextran sulfate sodium-induced acute murine ulcerative colitis

Author:

Qu Xinyan1ORCID,Li Qingjun23,Song Yue1,Xue Anqi1,Liu Yuhua1,Qi Dongmei23,Dong Hongjing4

Affiliation:

1. Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Shandong, China

2. Experimental Center, Shandong University of Traditional Chinese Medicine, Shandong, China

3. Key Laboratory of Basic Research of Traditional Chinese Medicine in Shandong Province, Shandong, China

4. Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Shandong, China

Abstract

Abstract Objectives Myricetin is a bioactive compound in many edible plants with anti-inflammatory and anticarcinogenic activity. The current study aimed to determine the protective effects and mechanism of myricetin against ulcerative colitis (UC). Methods Myricetin was orally administered at doses of 40 and 80 mg/kg to C57BL/6 mice with UC induced using dextran sulfate sodium. The disease-associated index and colon length were determined at the end of the experiment, the proportion of Treg, Th1 and Th17 was analysed by cytometry, and cytokines were detected using ELISA. Key findings Myricetin (80 mg/kg) ameliorated the severity of inflammation in acute UC and significantly improved the condition. Myricetin (80 mg/kg) elevated the levels of IL-10 and transforming growth factor β. In addition, the proportion of regulatory T cells significantly increased in mice in the myricetin treatment group. Conclusions Taking together, these results suggest that myricetin exhibits significant protective effects against UC and it could be used as a potential treatment for UC.

Funder

National Natural Science Foundation of China

Key Research and Development program of Shandong Province

Natural Foundation of Shandong Province

Foundation of Shandong University of Traditional Chinese Medicine for Youth

Foundation of Shandong Academy of Science for Youth

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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