Affiliation:
1. Drug Research and Development Center—NPDM, Federal University of Ceará, Fortaleza, Brazil
Abstract
Abstract
Objectives
Based on this, the central therapeutic effects of thymol were verified in the neurotrophic pathway.
Methods
Female swiss mice were divided into four groups: control, corticosterone (Cort), thymol (Cort + thymol) and fluvoxamine (Cort + Flu). The administration of corticosterone was used to induce depressive symptoms for 23 days. After the treatment, the animals were exposed the behavioural tests, such as forced swimming test, tail suspension test, sucrose preference test, light/dark test, social interaction test, Y-maze test, plus-maze test and hole-board test. The hippocampus was also removed, and BDNF was measured by ELISA and Western blot.
Key findings
As a result, thymol and fluvoxamine were able to reverse the depressive symptoms, as well as to improve the anxious frame. The anhedonic and short-term memory was restored with the treatment. In the neurochemical tests, both thymol and fluvoxamine restored BDNF levels, improving the depressive condition.
Conclusions
This work opens up new investigations aiming at the use of this molecule as a therapeutic alternative for treating depression disorders.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference67 articles.
1. A 5-HT 3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant;Bétry;Pharmacol Biochem Behav,2015
2. Modulation of OCT3 expression by stress, and antidepressant-like activity of decynium-22 in an animal model of depression;Marcinkiewcz;Pharmacol Biochem Behav,2015
3. Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders;Forte;J Affect Disord,2017
4. Effects of amycenone on serum levels of tumor necrosis factor- α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration;Yao;Pharmacol Biochem Behav,2015
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