Analysis of Clinical Isolates ofHelicobacter pyloriin Pakistan Reveals High Degrees of Pathogenicity and High Frequencies of Antibiotic Resistance

Author:

Rasheed Faisal12,Campbell Barry James1,Alfizah Hanafiah3,Varro Andrea4,Zahra Rabaab2,Yamaoka Yoshio56,Pritchard David Mark1

Affiliation:

1. Department of Gastroenterology; Institute of Translational Medicine; University of Liverpool; Liverpool L69 3GE UK

2. Department of Microbiology; Quaid-i-Azam University; Islamabad 45320 Pakistan

3. Department of Medical Microbiology & Immunology; Faculty of Medicine; Universiti Kebangsaan Malaysia Medical Centre; 56000 Cheras Kuala Lumpur Malaysia

4. Department of Cellular & Molecular Physiology; Institute of Translational Medicine; University of Liverpool; Liverpool L69 3GE UK

5. Department of Environmental and Preventive Medicine; Oita University Faculty of Medicine; Yufu 870-1192 Japan

6. Department of Medicine-Gastroenterology; Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine; Houston TX 77030 USA

Funder

Higher Education Commission (Pakistan)

Publisher

Wiley

Subject

Infectious Diseases,Gastroenterology,General Medicine

Reference72 articles.

1. Helicobacter pylori persistence: biology and disease;Blaser;J Clin Invest,2004

2. Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole and amoxicillin-influence on treatment outcome;Adamek;Am J Gastroenterol,1998

3. European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori;Glupczynski;Eur J Clin Microbiol Infect Dis,2001

4. Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori;Jeong;J Bacteriol,2000

5. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase;Goodwin;Mol Microbiol,1998

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