Affiliation:
1. Department of Molecular Physiology and Biophysics Vanderbilt University Nashville Tennessee USA
2. Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA
Abstract
AbstractThe article “Neuronal induction of BNIP3‐mediated mitophagy slows systemic aging in Drosophila” reveals BCL2‐interacting protein 3 as a therapeutic target to counteract brain aging and prolong overall organismal health with age. In this spotlight, we consider the roles of BNIP3, a mitochondrial outer membrane protein, in the adult nervous system, including its induction of mitophagy and prevention of dysfunctional mitochondria in the aged brain. Implications for other tissue types to reduce the burden of aging are further considered.
Funder
Burroughs Wellcome Fund
Chan Zuckerberg Initiative
National Institutes of Health
Bristol-Myers Squibb