Acquired haemophilia A in paediatric patients: A retrospective French cohort of eight cases

Author:

Mouthon Paul1ORCID,Guy Alexandre12,d'Oiron Roseline34,Harroche Annie5,Lebreton Aurélien67,Gourguechon Clément8,Oudot‐Challard Caroline9,Huguenin Yoann110

Affiliation:

1. Laboratory of Hematology Bordeaux University Hospital Pessac France

2. Univ. Bordeaux, Inserm, UMR1034, Biology of Cardiovascular Diseases Pessac France

3. Reference Centre for Haemophilia and Rare Bleeding Disorders, Bicêtre Hospital APHP, Paris‐Saclay University Le Kremlin‐Bicêtre France

4. INSERM, Hémostase inflammation thrombose HITH U1176, Paris‐Saclay University Le Kremlin‐Bicêtre France

5. Ressources and Competence Centre for Constitutional Bleeding Disorders, Necker Hospital, APHP Paris France

6. Laboratory of Hematology Clermont‐Ferrand University Hospital Clermont‐Ferrand France

7. University Clermont Auvergne, INRAE, UMR1019 Clermont‐Ferrand France

8. Department of Hematology Amiens University Hospital Amiens France

9. Ressources and Competence Centre for Constitutional Bleeding Disorders Toulouse Purpan University Hospital Toulouse France

10. Ressources and Competence Centre for Constitutional Bleeding Disorders Bordeaux University Hospital Bordeaux France

Abstract

SummaryAcquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new‐onset haemorrhagic symptoms associated with a dramatic decrease in factor VIII levels and an anti‐factor VIII neutralising autoantibody concentration >0.6 Bethesda units. Elderly people are often affected, whereas children are rarely affected; the paediatric incidence reported in the literature is about 0.045 case/million/year. For some time, the paediatric standard of care has been that for adults, but clinicians have often reported poor outcomes. Here, we describe the largest retrospective paediatric AHA cohort assembled to date, including eight patients diagnosed in France from 2000 to 2020.

Publisher

Wiley

Subject

Hematology

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