Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome-Reference-Cited by-同舟云学术

Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome

Published:2021-08-28 Issue:9 Volume:20 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Cabral Wayne A.¹,Tavarez Urraca L.¹,Beeram Indeevar²,Yeritsyan Diana²,Boku Yoseph D.¹,Eckhaus Michael A.³,Nazarian Ara²,Erdos Michael R.¹,Collins Francis S.¹

Affiliation:

1. Molecular Genetics Section Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA

2. Translational Musculoskeletal Innovation Initiative Carl J. Shapiro Department of Orthopedic Surgery Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA

3. Diagnostic and Research Services Branch Division of Veterinary Resources Office of the Director National Institutes of Health Bethesda MD USA

Funder

National Human Genome Research Institute

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13457

Reference45 articles.

1. Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

2. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model