Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation

Author:

Gordon I. O.1,Agrawal N.2,Willis E.1,Goldblum J. R.1,Lopez R.3,Allende D.1,Liu X.1,Patil D. Y.1,Yerian L.1,El-Khider F.4,Fiocchi C.45,Rieder F.45ORCID

Affiliation:

1. Department of Pathology; Robert J. Tomsich Pathology and Laboratory Medicine Institute; Cleveland Clinic Foundation; Cleveland OH USA

2. Department of Hospital Medicine; Medicine Institute; Cleveland Clinic Foundation; Cleveland OH USA

3. Department of Quantitative Health Sciences; Cleveland Clinic Foundation; Cleveland OH USA

4. Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute; Cleveland Clinic Foundation; Cleveland OH USA

5. Department of Pathobiology; Lerner Research Institute; Cleveland Clinic Foundation; Cleveland OH USA

Funder

National Institutes of Health

European Crohn's and Colitis Foundation

Cleveland Clinic Intramural Funding

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference37 articles.

1. Mechanisms of fibrosis: therapeutic translation for fibrotic disease;Wynn;Nat Med,2012

2. Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases;Rieder;Gastroenterology,2017

3. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease;Louis;Gut,2001

4. Radiographic findings of the National Cooperative Crohn's Disease Study;Goldberg;Gastroenterology,1979

5. The Roentgen findings in strictures of the colon associated with ulcerative and granulomatous colitis;Marshak;Am J Roentgenol Radium Ther Nucl Med,1963

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