Estimating and interpreting the pharmacokinetic profiles of individual patients with hemophilia A or B using a population pharmacokinetic approach: communication from the SSC of the ISTH

Author:

Iorio A.12ORCID,Blanchette V.3,Blatny J.4,Collins P.5,Fischer K.6,Neufeld E.7,

Affiliation:

1. Department of Health Research, Methods, Evidence and Impact; McMaster University; Hamilton Ontario Canada

2. Department of Medicine; McMaster University; Hamilton Ontario Canada

3. Division of Hematology/Oncology; Hospital for Sick Children and Department of Pediatrics; University of Toronto; Toronto Ontario Canada

4. Department of Pediatric Hematology; University Hospital Brno; Brno Czech Republic

5. Arthur Bloom Haemophilia Centre; School of Medicine; University Hospital of Wales; Cardiff University; Cardiff UK

6. Van Creveldkliniek; University Medical Center; Utrecht the Netherlands

7. St Jude Children's Research Hospital; Memphis TN USA

Publisher

Wiley

Subject

Hematology

Reference30 articles.

1. Lee M Morfini M Schulman S Ingerslev J the Factor VIII/Factor IX Scientific and Standardization Committee of the International Society for Thrombosis and Haemostasis. The design and analysis of pharmacokinetic studies of coagulation factors http://www.isth.org/Publications/OfficialCommunications/Factor8and9/Pharmacokinetic.asp

2. The design and analysis of half-life and recovery studies for factor VIII and factor IX. Factor VIII/Factor IX Scientific and Standardization Committee of the International Society for Thrombosis and Haemostasis;Morfini;Thromb Haemost,1991

3. Implications of coagulation factor VIII and IX pharmacokinetics in the prophylactic treatment of haemophilia;Collins;Haemophilia,2011

4. Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years;Björkman;Eur J Clin Pharmacol,2009

5. The use of pharmacokinetics in dose individualization of factor VIII in the treatment of hemophilia A;McEneny-King;Expert Opin Drug Metab Toxicol,2016

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