The analysis of semi‐competing risks data using Archimedean copula models

Author:

Wang Antai1ORCID,Guo Ziyan2,Zhang Yilong3,Wu Jihua4

Affiliation:

1. Department of Mathematical Sciences New Jersey Institute of Technology Newark New Jersey

2. Global Biometrics and Data Sciences Bristol Myers Squibb Berkeley Heights New Jersey

3. Department of Biostatistics and Research Decision Sciences Merck & CO., Inc Rahway New Jersey

4. Department of Biostatistics and Data Sciences BioRay Pharmaceutical Co., Ltd Zhejiang China

Abstract

In this paper, we derive the copula‐graphic estimator (Zheng and Klein) for marginal survival functions using Archimedean copula models based on competing risks data subject to univariate right censoring and prove its uniform consistency and asymptotic properties. We then propose a novel parameter estimation method based on the semi‐competing risks data using Archimedean copula models. Based on our estimation strategy, we propose a new model selection procedure. We also describe an easy way to accommodate possible covariates in data analysis using our strategies. Simulation studies have shown that our parameter estimate outperforms the estimator proposed by Lakhal, Rivest and Abdous for the Hougaard model and the model selection procedure works quite well. We fit a leukemia dataset using our model and end our paper with some discussion.

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,Statistics and Probability

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