The Role of CYP2C8 and CYP2C9 Genotypes in Losartan-Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes-Reference-Cited by-同舟云学术

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The Role of CYP2C8 and CYP2C9 Genotypes in Losartan-Dependent Inhibition of Paclitaxel Metabolism in Human Liver Microsomes

Published:2015-12-28 Issue:6 Volume:118 Page:408-414
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Mukai Yuji¹,Senda Asuna¹,Toda Takaki¹,Eliasson Erik²,Rane Anders²,Inotsume Nobuo¹

Affiliation:

1. Division of Clinical Pharmacology; Hokkaido Pharmaceutical University School of Pharmacy; Sapporo Japan

2. Division of Clinical Pharmacology; Department of Laboratory Medicine; Karolinska University Hospital; Karolinska Institute; Stockholm Sweden

Funder

Karolinska Institutet

Hokkaido Pharmaceutical University

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12520/fullpdf

Reference21 articles.

1. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance;Totah;Clin Pharmacol Ther,2005

2. Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interaction;Gao;Xenobiotica,2010

3. Impact of the CYP2C8*3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone;Aquilante;Br J Clin Pharmacol,2013

4. Losartan competitively inhibits CYP2C8-dependent paclitaxel metabolism in vitro;Mukai;Biol Pharm Bull,2014

5. Drug-drug interaction between losartan and paclitaxel in human liver microsomes with different CYP2C8 genotypes;Mukai;Basic Clin Pharmacol Toxicol,2015

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2. Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method;Chromatographia;2022-01-06

3. Co-administration of Fluvastatin and CYP3A4 and CYP2C8 Inhibitors May Increase the Exposure to Fluvastatin in Carriers of CYP2C9 Genetic Variants;Biological & Pharmaceutical Bulletin;2017

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