Comparable actions of omalizumab on mast cells and basophils

Author:

Serrano-Candelas E.12,Martinez-Aranguren R.3,Valero A.245,Bartra J.245,Gastaminza G.3,Goikoetxea M. J.3,Martín M.12,Ferrer M.3

Affiliation:

1. Biochemistry Unit; Faculty of Medicine; University of Barcelona; Barcelona Spain

2. Laboratory of Clinical and Experimental Respiratory Immunoallergy; IDIBAPS; Barcelona Spain

3. Department of Allergy and Clinical Immunology; Clinica Universidad de Navarra; Instituto de Investigación Sanitaria de Navarra (IDISNA); Pamplona Spain

4. Department of Pneumology and Allergy; Immunoallèrgia Respiratòria Clínica I Experimental; IDIBAPS; Hospital Clínic; Barcelona Spain

5. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES); Barcelona Spain

Funder

Novartis Spain

Health Research Fund

Spanish Ministry of Economy and Competitiveness (Fondo de Investigaciones Sanitarias, Ministerio de Economía y Competitividad)

Carlos III Health Institute of Spain

Spanish Research Network on Adverse Reactions to Allergens and Drugs (RIRAAF: Red de Investigación de Reacciones Adversas Alérgenos y Fármacos) of the Carlos III Health Institute

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference43 articles.

1. Humanization of an antibody directed against IgE;Presta;J Immunol,1993

2. Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab;Zheng;Biochem Biophys Res Commun,2008

3. Anti-IgE-emerging opportunities for Omalizumab;Babu;Expert Opin Biol Ther,2013

4. Omalizumab, an anti-immunoglobulin E antibody: state of the art;Incorvaia;Drug Drug Des Devel Ther,2014

5. Omalizumab-induced reductions in mast cell Fce psilon RI expression and function;Beck;J Allergy Clin Immunol,2004

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