Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors

Author:

Boull Christina1,Hook Kristen1,Moertel Christopher2,Maguiness Sheilagh1

Affiliation:

1. Division of Pediatric Dermatology; Department of Dermatology; University of Minnesota; Minneapolis Minnesota

2. Department of Pediatric Hematology/Oncology; University of Minnesota; Minneapolis Minnesota

Publisher

Wiley

Subject

Dermatology,Pediatrics, Perinatology, and Child Health

Reference11 articles.

1. The clinical development of MEK inhibitors;Zhao;Nat Rev Clin Oncol,2014

2. A randomized phase II study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small-cell lung cancer (NSCLC);Blumenschein;Ann Oncol,2015

3. Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor;Kim;J Clin Oncol,2013

4. National Cancer Institute Common Terminology Criteria for Adverse Events v4.0 NCI, NIH, DHHS. May 29, 2009 NIH publication 09-7473 http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf

5. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations;Flaherty;N Engl J Med,2012

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