Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

Author:

Huo Xiaokui1,Wang Chao1,Yu Zhenlong1,Peng Yulin1,Wang Shumei2,Feng Shengnan1,Zhang Shouji1,Tian Xiangge1,Sun Chengpeng1,Liu Kexin1,Deng Sa1,Ma Xiaochi12ORCID

Affiliation:

1. Key Laboratory of Pharmacokinetic and Drug Transport of Liaoning; College of Pharmacy; Academy of Integrative Medicine; Dalian Medical University; Dalian China

2. Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM; Guangdong Pharmaceutical University; Guangdong China

Funder

National Natural Science Foundation of China

Dalian Outstanding Youth Science and Technology Talent

Distinguished professor of Liaoning Province

Innovation Team of Dalian Medical University

Publisher

Wiley

Subject

Endocrinology

Reference64 articles.

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2. Isolation of melatonin and 5-methoxyindole-3-acetic acid from bovine pineal glands;Lerner;J Biol Chem,1960

3. Melatonin membrane receptors in peripheral tissues: distribution and functions;Slominski;Mol Cell Endocrinol,2012

4. Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesis;Jan;J Pineal Res,2011

5. Pharmacology and function of melatonin receptors;Dubocovich;FASEB J,1988

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