Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s
Author:
Affiliation:
1. Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit; AstraZeneca; Gothenburg Sweden
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.14203/fullpdf
Reference47 articles.
1. The Concise Guide to PHARMACOLOGY 2017/18: Enzymes;Alexander;Br J Pharmacol,2017
2. Evaluation of a new molecular entity as a victim of metabolic drug-drug interactions-an industry perspective;Bohnert;Drug Metab Dispos,2016
3. Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity;Brynne;Br J Clin Pharmacol,1999
4. Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects;Chaikin;Br J Clin Pharmacol,2005
5. Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam;Chen;Drug Metab Dispos,2006
Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Simultaneously Predicting Pharmacokinetics of Loratadine and Desloratadine in Children Using a Whole‐Body Physiologically Based Pharmacokinetic Model;The Journal of Clinical Pharmacology;2024-08-22
2. Evaluation and Optimization of a Microcavity Plate–Based Human Hepatocyte Spheroid Model for Predicting Clearance of Slowly Metabolized Drug Candidates;Drug Metabolism and Disposition;2024-05-22
3. Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline;Frontiers in Pharmacology;2023-10-04
4. Enhancing drug-drug Interaction Prediction by Integrating Physiologically-Based Pharmacokinetic Model with Fraction Metabolized by CYP3A4;Expert Opinion on Drug Metabolism & Toxicology;2023-09-30
5. Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects;Drug Metabolism and Disposition;2023-07-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3