Functional connectomes of akinetic‐rigid and tremor within drug‐naïve Parkinson's disease

Author:

Wu Haoting1,Zhou Cheng1,Guan Xiaojun1ORCID,Bai Xueqin1,Guo Tao1,Wu Jingjing1,Chen Jingwen1,Wen Jiaqi1,Wu Chenqing1,Cao Zhengye1,Liu Xiaocao1,Gao Ting2,Gu Luyan2,Huang Peiyu1ORCID,Xu Xiaojun1ORCID,Zhang Baorong2ORCID,Zhang Minming1ORCID

Affiliation:

1. Department of Radiology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

2. Department of Neurology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

Abstract

AbstractAimsTo detect functional connectomes of akinetic‐rigid (AR) and tremor and compare their connection pattern.MethodsResting‐state functional MRI data of 78 drug‐naïve PD patients were enrolled to construct connectomes of AR and tremor via connectome‐based predictive modeling (CPM). The connectomes were further validated with 17 drug‐naïve patients to verify their replication.ResultsThe connectomes related to AR and tremor were identified via CPM method and successfully validated in the independent set. Additional regional‐based CPM demonstrated neither AR nor tremor could be simplified to functional changes within a single brain region. Computational lesion version of CPM revealed that parietal lobe and limbic system were the most important regions among AR‐related connectome, and motor strip and cerebellum were the most important regions among tremor‐related connectome. Comparing two connectomes found that the patterns of connection between them were largely distinct, with only four overlapped connections identified.ConclusionAR and tremor were found to be associated with functional changes in multiple brain regions. Distinct connection patterns of AR‐related and tremor‐related connectomes suggest different neural mechanisms underlying the two symptoms.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

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