Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib

Author:

Rapposelli Ilario Giovanni1,Tada Toshifumi2ORCID,Shimose Shigeo3ORCID,Burgio Valentina4,Kumada Takashi5ORCID,Iwamoto Hideki3,Hiraoka Atsushi6ORCID,Niizeki Takashi3,Atsukawa Masanori7ORCID,Koga Hironori3,Hirooka Masashi8,Torimura Takuji3ORCID,Iavarone Massimo9,Tortora Raffaella10,Campani Claudia11,Lonardi Sara1213,Tamburini Emiliano14,Piscaglia Fabio15ORCID,Masi Gianluca16,Cabibbo Giuseppe17ORCID,Giuseppe Foschi Francesco18,Silletta Marianna19,Tsuji Kunihiko20,Ishikawa Toru21,Takaguchi Koichi22,Kariyama Kazuya23,Itobayashi Ei24,Tajiri Kazuto25ORCID,Shimada Noritomo26,Shibata Hiroshi27,Ochi Hironori28,Yasuda Satoshi29ORCID,Toyoda Hidenori29ORCID,Fukunishi Shinya30,Ohama Hideko30,Kawata Kazuhito31ORCID,Tani Joji32,Nakamura Shinichiro2,Nouso Kazuhiro23ORCID,Tsutsui Akemi22,Nagano Takuya22,Tanaka Takaaki6,Itokawa Norio7,Okubo Tomomi7,Arai Taeang7,Imai Michitaka21,Joko Kouji28ORCID,Koizumi Yohei8,Hiasa Yoichi8ORCID,Rimini Margherita33,Ratti Francesca34,Aldrighetti Luca34,Cascinu Stefano435,Casadei‐Gardini Andrea435ORCID

Affiliation:

1. Department of Medical Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"‐IRST Meldola Italy

2. Department of Internal Medicine Japanese Red Cross Himeji Hospital Himeji Japan

3. Division of Gastroenterology Department of Medicine Kurume University School of Medicine Kurume, Fukuoka Japan

4. Department of Medical Oncology San Raffaele Scientific Institute IRCCS Milan Italy

5. Faculty of Nursing Gifu Kyoritsu University Ogaki Japan

6. Gastroenterology Center Ehime Prefectural Central Hospital Matsuyama Japan

7. Division of Gastroenterology and Hepatology Department of Internal Medicine Nippon Medical School Tokyo Japan

8. Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Matsuyama Japan

9. Division of Gastroenterology and Hepatology Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano Milan Italy

10. Liver Unit Cardarelli Hospital Naples Italy

11. Department of Experimental and Clinical Biomedical Sciences "Mario Serio" University of Florence Florence Italy

12. Early Phase Clinical Trial Unit Department of Oncology Veneto Institute of Oncology IOV‐IRCCS Padua Italy

13. Medical Oncology Unit 1 Department of Oncology Veneto Institute of Oncology IOV‐IRCCS Padua Italy

14. Department of Medical Oncology Card. G. Panico Hospital of Tricase Tricase Italy

15. Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases Azienda Ospedaliero Universitaria di Bologna Italy

16. Azienda Ospedaliero‐Universitaria Pisana Pisa Italy

17. Department of Health Promotion Mother & Child Care Internal Medicine & Medical Specialties PROMISE Gastroenterology & Hepatology Unit University of Palermo Palermo Italy

18. Department of Internal Medicine Faenza HospitalAUSL Romagna Faenza Italy

19. Medical Oncology Unit University Campus Bio‐Medico Rome Italy

20. Center of Gastroenterology Teine Keijinkai Hospital Sapporo Japan

21. Department of Gastroenterology Saiseikai Niigata Hospital Niigata Japan

22. Department of Hepatology Kagawa Prefectural Central Hospital Takamatsu Japan

23. Department of Gastroenterology Okayama City Hospital Okayama Japan

24. Department of Gastroenterology Asahi General Hospital Asahi Japan

25. Department of Gastroenterology Toyama University Hospital Toyama Japan

26. Division of Gastroenterology and Hepatology Otakanomori Hospital Kashiwa Japan

27. Department of Gastroenterology Tokushima Prefectural Central Hospital Tokushima Japan

28. Hepato‐biliary Center Matsuyama Red Cross Hospital Matsuyama Japan

29. Department of Gastroenterology and Hepatology Ogaki Municipal Hospital Ogaki Japan

30. Second Department of Internal Medicine Osaka Medical College Takatsuki Japan

31. Hepatology Division Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan

32. Department of Gastroenterology and Neurology Kagawa University School of Medicine Kagawa Japan

33. Division of Oncology Department of Oncology and Hematology University Hospital of Modena Modena Italy

34. Hepatobiliary Surgery Division IRCCS San Raffaele Scientific Institute Milan Italy

35. Vita‐Salute San Raffaele University Milan Italy

Publisher

Wiley

Subject

Hepatology

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