Influence ofUGT2B7,OPRM1andABCB1 Gene Polymorphisms on Postoperative Morphine Consumption

Author:

Bastami Salumeh1,Gupta Anil2,Zackrisson Anna-Lena3,Ahlner Johan13,Osman Abdimajid4,Uppugunduri Srinivas4

Affiliation:

1. Unit for Development and Patient Safety; Department of Medical and Health Sciences; Linköping University; Linköping Sweden

2. Department of Anesthesia and Intensive Care; Örebro University; Örebro Sweden

3. Department of Forensic Genetics and Forensic Toxicology; National Board of Forensic Medicine; Linköping Sweden

4. Department of Clinical Chemistry and Department of Clinical and Experimental Medicine; Linköping University; Linköping Sweden

Funder

National Board of Health and Welfare in Sweden

Swedish Academy of Pharmaceutical Sciences (SAPS)

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference28 articles.

1. A retrospective study of the association between haematological and biochemical parameters and morphine intolerance in patients with cancer pain;Riley;Palliat Med,2004

2. The minimum effective concentration of opioids: a revisitation with patient controlled analgesia fentanyl;Woodhouse;Reg Anesth Pain Med,2000

3. Human UGT2B7 catalyzes morphine glucuronidation;Coffman;Drug Metab Dispos,1997

4. Morphine metabolism, transport and brain disposition;De Gregori;Metab Brain Dis,2012

5. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268);Coffman;Drug Metab Dispos,1998

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