High-Content Analysis/Screening for Predictive Toxicology: Application to Hepatotoxicity and Genotoxicity

Author:

Persson Mikael1,Løye Anni F.1,Jacquet Mélanie1,Mow Natacha S.1,Thougaard Annemette V.1,Mow Tomas1,Hornberg Jorrit J.1

Affiliation:

1. Department of Exploratory Toxicology; Non-Clinical Safety Research; H. Lundbeck A/S Valby Denmark

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference29 articles.

1. Exploratory toxicology as an integrated part of drug discovery - Part I: why and how;Hornberg;Drug Discov Today,2013

2. Exploratory toxicology as an integrated part of drug discovery - Part II: screening strategies;Hornberg;Drug Discov Today,2013

3. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening;O'Brien;Arch Toxicol,2006

4. Cellular imaging predictions of clinical drug-induced liver injury;Xu;Toxicol Sci,2008

5. A high content screening assay to predict human drug-induced liver injury during drug discovery;Persson;J Pharmacol Toxicol Methods,2013

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