The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

Author:

Branchford B. R.12ORCID,Stalker T. J.3,Law L.1,Acevedo G.1,Sather S.1,Brzezinski C.1,Wilson K. M.4,Minson K.56,Lee-Sherick A. B.1,Davizon-Castillo P.1,Ng C.12,Zhang W.7,Neeves K. B.8,Lentz S. R.4,Wang X.7,Frye S. V.79,Shelton Earp H.910,DeRyckere D.56,Brass L. F.3,Graham D. K.56,Di Paola J. A.1211

Affiliation:

1. Department of Pediatrics; Section of Hematology/Oncology; University of Colorado School of Medicine; Aurora CO USA

2. University of Colorado Hemophilia and Thrombosis Center; Aurora CO USA

3. Department of Medicine; University of Pennsylvania; Philadelphia PA USA

4. Carver College of Medicine; University of Iowa; Iowa City IA USA

5. Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta; Atlanta GA USA

6. Department of Pediatrics; Section of Hematology/Oncology; Emory University School of Medicine; Atlanta GA USA

7. Center for Integrative Chemical Biology and Drug Discovery; Division of Chemical Biology and Medicinal Chemistry; Eshelman School of Pharmacy; University of North Carolina; Chapel Hill NC USA

8. Department of Chemical & Biological Engineering; Colorado School of Mines; Golden CO USA

9. Lineberger Comprehensive Cancer Center; Department of Medicine; School of Medicine; University of North Carolina; Chapel Hill NC USA

10. Department of Pharmacology; University of North Carolina at Chapel Hill; Chapel Hill NC USA

11. Graduate Program - Human Medical Genetics; University of Colorado School of Medicine; Aurora CO USA

Funder

National Hemophilia Foundation

American Society of Hematology

CSL Behring

National Institutes of Health

Child Health Research Career Development grant

Hemostasis and Thrombosis Research Society

Shire

Postle Chair

University Cancer Research Fund

Federal Funds

National Cancer Institute

Publisher

Wiley

Subject

Hematology

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