Association between longitudinal changes in body composition and the risk of kidney outcomes in participants with overweight/obesity and type 2 diabetes mellitus

Author:

Zu Cheng12,Liu Mengyi345,Wang Gangling12,Meng Qiguo12,Gan Xiaoqin345,He Panpan345,Zhou Chun345,Ye Ziliang345,Wei Yuanxiu12,Su Xinyue12,Zhang Yuanyuan345,Qin Xianhui12345ORCID

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health Anhui Medical University Hefei China

2. Institute of Biomedicine Anhui Medical University Hefei China

3. Division of Nephrology, Nanfang Hospital Southern Medical University Guangzhou China

4. National Clinical Research Center for Kidney Disease Guangzhou China

5. State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou China

Abstract

AbstractAimsTo assess the relationship of longitudinal changes in fat mass (FM), lean mass (LM) and waist circumference (WC) with incident kidney outcomes in people with overweight/obesity and type 2 diabetes mellitus (T2DM).Materials and MethodsA total of 3927 participants with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 from the Look AHEAD (Action for Health in Diabetes) trial were included. The primary outcome was kidney outcomes, defined as a decrease in eGFR of at least 40% from baseline at follow‐up visit, or end‐stage kidney disease.ResultsDuring a median follow‐up of 8.0 years, 450 kidney outcomes were documented after the first 1 year. In the intensive lifestyle intervention (ILI) group, reductions in FM (per 10% decrease, adjusted hazard ratio [HR] 0.80, 95% confidence interval [CI] 0.69–0.94) and WC (per 10% decrease, adjusted HR 0.72, 95% CI 0.59–0.88) from baseline to 1‐year follow‐up were significantly associated with a lower risk of kidney outcomes. The change in LM was not significantly associated with risk of kidney outcomes (per 10% decrease, adjusted HR 0.78, 95% CI 0.58–1.06). In the diabetes support and education group (control group), no significant association was found between changes in body composition and kidney outcomes. Similar results were observed for the 4‐year changes in body composition.ConclusionsIn this post hoc analysis of the Look AHEAD trial, longitudinal declines in FM and WC were associated with a lower risk of kidney outcomes in the ILI group in participants with overweight/obesity and T2DM.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Wiley

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