Noninvasive evaluation of donor and native pancreases following simultaneous pancreas–kidney transplantation using positron emission tomography/computed tomography-Reference-Cited by-同舟云学术

Noninvasive evaluation of donor and native pancreases following simultaneous pancreas–kidney transplantation using positron emission tomography/computed tomography

Published:2023-06-28 Issue:10 Volume:14 Page:1187-1191
ISSN:2040-1116
Container-title:Journal of Diabetes Investigation
language:en
Short-container-title:J of Diabetes Invest

Author:

Murakami Takaaki¹^ORCID,Nakamura Toshihiro¹^ORCID,Fujimoto Hiroyuki²,Fujikura Junji¹,Shimizu Yoichi³,Miyake Kanae K.⁴,Otani Daisuke¹,Sakaki Kentaro¹,Kiyobayashi Sakura¹,Anazawa Takayuki⁵,Nakamoto Yuji³,Inagaki Nobuya¹⁶^ORCID

Affiliation:

1. Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine Kyoto University Kyoto Japan

2. Radioisotope Research Center, Agency for Health, Safety and Environment Kyoto University Kyoto Japan

3. Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine Kyoto University Kyoto Japan

4. Department of Advanced Medical Imaging Research, Graduate School of Medicine Kyoto University Kyoto Japan

5. Division of Hepato‐Biliary‐Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine Kyoto University Kyoto Japan

6. Medical Research Institute Kitano Hospital, PIIF Tazuke‐kofukai Osaka Japan

Abstract

ABSTRACTIt is crucial to develop practical and noninvasive methods to assess the functional beta‐cell mass in a donor pancreas, in which monitoring and precise evaluation is challenging. A patient with type 1 diabetes underwent noninvasive imaging following simultaneous kidney–pancreas transplantation with positron emission tomography/computed tomography (PET/CT) using an exendin‐based probe, [18F]FB(ePEG12)12‐exendin‐4. Following transplantation, PET imaging with [18F]FB(ePEG12)12‐exendin‐4 revealed simultaneous and distinct accumulations in the donor and native pancreases. The pancreases were outlined at a reasonable distance from the surrounding organs using [18F]FB(ePEG12)12‐exendin‐4 whole‐body maximum intensity projection and axial PET images. At 1 and 2 h after [18F]FB(ePEG12)12‐exendin‐4 administration, the mean standardized uptake values were 2.96 and 3.08, respectively, in the donor pancreas and 1.97 and 2.25, respectively, in the native pancreas. [18F]FB(ePEG12)12‐exendin‐4 positron emission tomography imaging allowed repeatable and quantitative assessment of beta‐cell mass following simultaneous kidney–pancreas transplantation.

Funder

Manpei Suzuki Diabetes Foundation

Suzuken Memorial Foundation

Publisher

Wiley

Subject

General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdi.14045

Reference16 articles.

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3. Non-invasive Beta-cell Imaging: Visualization, Quantification, and Beyond

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5. Inside the pancreas: progress and challenges of human beta cell mass quantification

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1. 18F-labeled PEGylated exendin-4 imaging noninvasively differentiates insulinoma from an accessory spleen: the first case report of [18F]FB(ePEG12)12-exendin-4 positron emission tomography/computed tomography for insulinoma;Frontiers in Endocrinology;2023-08-31