Investigation of <scp>CYP3A</scp> induction by <scp>PF</scp> ‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response-Reference-Cited by-同舟云学术

Investigation of CYP3A induction by PF ‐05251749 in early clinical development: comparison of linear slope physiologically based pharmacokinetic prediction and biomarker response

Published:2022-07-02 Issue:9 Volume:15 Page:2184-2194
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Lin Jian¹,Gaudreault Francois²,Johnson Nathaniel¹,Lin Zhiwu¹,Nouri Parya³,Goosen Theunis C.¹,Sawant‐Basak Aarti²

Affiliation:

1. Medicine Design Pharmacokinetics, Pharmacodynamics, and Metabolism, Worldwide Research, Development and Medical Pfizer Inc. Groton Connecticut USA

2. Clinical Pharmacology, Early Clinical Development, Worldwide Research, Development and Medical Pfizer Inc. Cambridge Massachusetts USA

3. Clinical Assay Group Global Product Development, Pfizer Inc. Cambridge Massachusetts USA

Funder

Pfizer

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13352

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1. MAMMALIAN CIRCADIAN BIOLOGY: Elucidating Genome-Wide Levels of Temporal Organization

2. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

3. Pharmacokinetic Drug Interactions with Rifampicin

4. Clinically Significant Pharmacokinetic Drug Interactions with Carbamazepine

5. Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

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