Model‐informed drug development for immuno‐oncology agonistic <scp>anti‐GITR</scp> antibody <scp>GWN323</scp> : Dose selection based on <scp>MABEL</scp> and biologically active dose-Reference-Cited by-同舟云学术

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Model‐informed drug development for immuno‐oncology agonistic anti‐GITR antibody GWN323 : Dose selection based on MABEL and biologically active dose

Published:2022-07-19 Issue:9 Volume:15 Page:2218-2229
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Ji Yan¹^ORCID,Knee Deborah²,Chen Xinhui¹^ORCID,Dang Anhthu³,Mataraza Jennifer³,Wolf Babette⁴,Sy Sherwin K. B.¹^ORCID

Affiliation:

1. Novartis Pharmaceuticals Corporation East Hanover New Jersey USA

2. Novartis Institutes for BioMedical Research San Diego California USA

3. Novartis Institutes for BioMedical Research Cambridge Massachusetts USA

4. Novartis Institutes for BioMedical Research Basel Switzerland

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13355

Reference30 articles.

1. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives

2. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

3. GITR: A Modulator of Immune Response and Inflammation

4. Glucocorticoid-induced TNFR-related gene (GITR) as a therapeutic target for immunotherapy

5. Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

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1. Pharmacokinetic models for first-in-human dose selection of immune-activating products in oncology;Regulatory Toxicology and Pharmacology;2024-05

2. Utility and impact of quantitative pharmacology on dose selection and clinical development of immuno-oncology therapy;Cancer Chemotherapy and Pharmacology;2024-03-02

3. Transcriptomic analysis of GITR and GITR ligand reveals cancer immune heterogeneity with implications for GITR targeting;American Journal of Cancer Research;2024

4. Towards in vitro models for reducing or replacing the use of animals in drug testing;Nature Biomedical Engineering;2023-12-27

5. Practical Application of Pk/TK Models: Preclinical PK/TK and Clinical Trial;Handbook of Pharmacokinetics and Toxicokinetics;2023-07-03

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