Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?
Author:
Publisher
Wiley
Subject
Clinical Neurology,Neurology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1528-1167.2007.01260_3.x/fullpdf
Reference22 articles.
1. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein;Baltes;Neuropharmacology,2007
2. Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine;Drion;J Neurochem,1996
3. Human brain phenytoin: correlation with unbound and total serum concentrations;Friel;Epilepsy Res,1989
4. Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydr o-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations;Harrison;Drug Metab Dispos,2004
5. Distribution of anticonvulsant drugs in gray and white matter of human brain;Harvey;Can J Neurol Sci,1977
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