Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5-Reference-Cited by-同舟云学术

Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5

Published:2022-09-20 Issue:11 Volume:15 Page:2720-2731
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clinical Translational Sci

Author:

Collins Joseph M.¹,Nworu Adaeze C.¹,Mohammad Somayya J.²,Li Liang³^ORCID,Li Chengcheng³,Li Chuanjiang⁴,Schwendeman Ethan²,Cefalu Mattew²,Abdel‐Rasoul Mahmoud⁵,Sun Jessie W.²⁶,Smith Sakima A.²,Wang Danxin¹^ORCID

Affiliation:

1. Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy University of Florida Gainesville Florida USA

2. Department of Internal Medicine, Division of Cardiology, College of Medicine The Ohio State University Columbus Ohio USA

3. Department of Medical Genetics, School of Basic Medical Sciences Southern Medical University Guangzhou China

4. Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital Southern Medical University Guangzhou China

5. Center for Biostatistics, Department of Biomedical Informatics, College of Medicine The Ohio State University Columbus Ohio USA

6. School of Medicine and Health Sciences George Washington University Washington DC USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13398

Reference39 articles.

1. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

2. Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

3. THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

4. Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review

5. Genetic epidemiology of induced CYP3A4 activity

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