International Council for Standardization in Haematology (ICSH) recommendations for the performance and interpretation of activated partial thromboplastin time and prothrombin time mixing tests

Author:

Adcock D. M.1,Moore G. W.23ORCID,Kershaw G. W.4,Montalvao S. A. L.5ORCID,Gosselin R. C.6ORCID

Affiliation:

1. Retired Labcorp Burlington North Carolina USA

2. Department of Haematology, Specialist Haemostasis Unit Cambridge University Hospitals Foundation Trust Cambridge UK

3. Department of Natural Sciences Middlesex University London UK

4. Institute of Haematology Royal Prince Alfred Hospital Sydney New South Wales Australia

5. Laboratory Hemostasis and Thrombosis, Hematology and Hemotherapy Center University of Campinas UNICAMP Campinas Brazil

6. Hemostasis and Thrombosis Center University of California, Davis Health System Sacramento California USA

Abstract

AbstractThis guidance document has been prepared on behalf of the International Council for Standardization in Haematology (ICSH). The aim of the document is to provide guidance and recommendations for the performance and interpretation of activated partial thromboplastin time (APTT) and prothrombin time (PT) plasma mixing tests in clinical laboratories in all regions of the world. The following areas are included in this document: preanalytical, analytical, postanalytical, and quality assurance considerations as they relate to the proper performance and interpretation of plasma mixing tests. The recommendations are based on good laboratory practice, published data in peer‐reviewed literature, and expert opinion.

Publisher

Wiley

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