Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability

Author:

Mian P.1ORCID,Esdonk M. J.23,Olkkola K. T.4,Winter B. C. M.5,Liukas A.6,Spriet I.7,Tibboel D.1,Petrovic M.8,Koch B. C. P.5,Allegaert K.1910ORCID

Affiliation:

1. Intensive Care and Department of Paediatric SurgeryErasmus MC Sophia Children's Hospital Rotterdam The Netherlands

2. Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug ResearchLeiden University Leiden The Netherlands

3. Centre for Human Drug Research Leiden The Netherlands

4. Department of AnaesthesiologyIntensive Care and Pain Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland

5. Department of Hospital PharmacyErasmus MC Rotterdam The Netherlands

6. Department of AnaesthesiologyTurku University Hospital Turku Finland

7. Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven and Pharmacy DepartmentUniversity Hospital Leuven Leuven Belgium

8. Department of GeriatricsGhent University Hospital Ghent Belgium

9. Department of Development and RegenerationKU Leuven Leuven Belgium

10. Department of Paediatrics, Division of NeonatologyErasmus MC Sophia Children's Hospital Rotterdam The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. United Nations. Ageing. Available at:http://www.un.org/en/sections/issues‐depth/ageing/index.html(last accessed 22 June 2018).

2. Management of Chronic Arthritis Pain in the Elderly

3. Pharmacotherapies in Geriatric Chronic Pain Management

4. Management of Postoperative Analgesia in Elderly Patients

5. Guidance on the management of pain in older people

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