Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-β-induced regulatory T-cell development

Author:

Battaglia Alessandra1,Buzzonetti Alexia1,Baranello Cinzia2,Fanelli Mara2,Fossati Marco1,Catzola Valentina1,Scambia Giovanni1,Fattorossi Andrea1

Affiliation:

1. Department of Obstetrics and Gynaecology; Università Cattolica S. Cuore; Rome; Italy

2. Department of Oncology; Fondazione di Ricerca e Cura “Giovanni Paolo II”; Università Cattolica S. Cuore; Campobasso; Italy

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference43 articles.

1. Interleukin-2: clinical applications;Atkins;Semin Oncol,2002

2. Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion;Powell;J Immunol,2006

3. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome;Cotran;J Immunol,1988

4. Tolerance, not immunity, crucially depends on IL-2;Malek;Nat Rev Immunol,2004

5. IL-2 administration increases CD4+ CD25hi Foxp3+ regulatory T cells in cancer patients;Ahmadzadeh;Blood,2006

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