Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening

Author:

Damon C.1,Luck M.12,Toullec L.3,Etienne I.4,Buchler M.5,Hurault de Ligny B.6,Choukroun G.7,Thierry A.8,Vigneau C.9,Moulin B.10,Heng A.-E.11,Subra J.-F.12,Legendre C.13,Monnot A.1,Yartseva A.1,Bateson M.1,Laurent-Puig P.2314,Anglicheau D.13,Beaune P.2314,Loriot M. A.2314,Thervet E.215,Pallet N.231415

Affiliation:

1. Hypercube Institute; Paris France

2. Paris Descartes University; Paris France

3. Department of Clinical Chemistry; Georges Pompidou European Hospital; Assistance Publique Hôpitaux de Paris; Paris France

4. Department of Nephrology; Rouen University Hospital; Rouen France

5. Department of Nephrology; Tours University Hospital; Tours France

6. Department of Nephrology; Caen University Hospital; Caen France

7. Department of Nephrology; Amiens University Hospital; Amiens France

8. Department of Nephrology; Poitiers University Hospital; Poitiers France

9. Department of Nephrology; Rennes University Hospital; Rennes France

10. Department of Nephrology; Strasbourg University Hospital; Strasbourg France

11. Department of Nephrology; Clermont-Ferrand University Hospital; Clermont-Ferrand France

12. Department of Nephrology; Angers University Hospital; Angers France

13. Department of Nephrology; Necker Hospital; Assistance Publique Hôpitaux de Paris; Paris France

14. Institut National pour la Santé et la Recherche Médicale (INSERM) U1147; Paris France

15. Department of Nephrology; Georges Pompidou European Hospital; Assistance Publique Hôpitaux de Paris; Paris France

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference29 articles.

1. The role of pharmacogenomic biomarkers in predicting and improving drug response: Part 2: Challenges impeding clinical implementation;Ventola;P T,2014

2. Role of pharmacogenomic biomarkers in predicting and improving drug response: Part 1: The clinical significance of pharmacogenetic variants;Ventola;P T,2013

3. Pharmacogenetics in the evaluation of new drugs: A multiregional regulatory perspective;Maliepaard;Nat Rev Drug Discov,2013

4. Opportunities to optimize tacrolimus therapy in solid organ transplantation: Report of the European consensus conference;Wallemacq;Ther Drug Monit,2009

5. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients;Elens;Clin Chem,2011

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