Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist
Author:
Affiliation:
1. Department of Medical Genetics; University of Alberta; Edmonton AB Canada
2. Rhythm Pharmaceuticals; Boston MA USA
3. Department of Pharmacology; University of Alberta; Edmonton AB Canada
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.13540/fullpdf
Reference25 articles.
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2. Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome;Bischof;Hum Mol Genet,2007
3. RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals;Chen;J Clin Endocrinol Metab,2015
4. Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice;Clemmensen;EMBO Mol Med,2015
5. Experimental design and analysis and their reporting: new guidance for publication in BJP;Curtis;Br J Pharmacol,2015
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