Lipofibromatosis‐like neural tumors: Report of a case and review of 73 reported cases

Abstract

AbstractLipofibromatosis‐like neural tumors (LPF‐NTs) are a recently discovered group of spindle cell tumors defined by the presence of a lipofibromatosis‐like pattern, CD34 and/or S100 reactivity, and frequent neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangements. As new cases emerge, the spectrum of features observed in LPF‐NTs continues to evolve. Here we describe the case of an 11‐year‐old with LPF‐NT with a dermatofibrosarcoma protuberans‐like honeycomb pattern, CD34 and S100 co‐expression, and an NTRK1 rearrangement. We also review the clinical and molecular features of the 73 cases of LPF‐NT previously described in the literature.