HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT

Author:

Huang Tao12ORCID,Wang Tiange23,Heianza Yoriko2,Sun Dianjianyi2,Ivey Kerry4,Durst Ronen56,Schwarzfuchs Dan7,Stampfer Meir J.489,Bray George A.10,Sacks Frank M.4,Shai Iris11,Qi Lu249

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health; Peking University; Beijing China

2. Department of Epidemiology, School of Public Health and Tropical Medicine; Tulane University; New Orleans Louisana

3. Shanghai Institute of Endocrine and Metabolic Diseases; Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai China

4. Department of Nutrition; Harvard T.H. Chan School of Public Health; Boston Massachusetts

5. Cardiology Department; Hadassah Hebrew University Medical Center; Jerusalem Israel

6. Center for Research Prevention and Treatment of Atherosclerosis, Internal Medicine Department; Hadassah Hebrew University Medical Center; Jerusalem Israel

7. The Nuclear Research Centre, Dimona; Israel

8. Department of Epidemiology; Harvard T.H. Chan School of Public Health; Boston Massachusetts

9. Channing Division of Network Medicine, Department of Medicine; Brigham and Women’s Hospital and Harvard Medical School; Boston Massachusetts

10. Pennington Biomedical Research Center of the Louisiana State University System; Baton Rouge Lousiana

11. Department of Public Health; Ben Gurion University of the Negev; Beer Sheva Israel

Funder

American Heart Association

Boston Obesity Nutrition Research Center

General Clinical Research Center

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference31 articles.

1. Genetics of common forms of glycaemia with pathological impact on vascular biology: are we on the right track?;Andersen;Curr Mol Med,2005

2. Genetic evidence that HNF-1 alpha-dependent transcriptional control of HNF-4 alpha is essential for human pancreatic beta cell function;Hansen;J Clin Invest,2002

3. Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells;Donelan;J Biol Chem,2010

4. HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community;Triggs-Raine;Proc Natl Acad Sci U S A,2002

5. Glucose-lowering effects and low risk of hypoglycemia in patients with maturity-onset diabetes of the young when treated with a GLP-1 receptor agonist: a double-blind, randomized, crossover trial;Ostoft;Diabetes Care,2014

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