Glutamic‐acid grafted hyaluronic acid inhibits inflammatory factors via fibroblast and skin model tests

Abstract

AbstractBackgroundExcessive inflammation may cause tissue damage and disrupt the function of the skin barrier. Hyaluronic acid (HA), an endogenous component, was found to regulate multiple inflammatory factors for skin health. This work aims to further enhance its efficacy by grafting amino acid onto its molecule.MethodsGlutamic acid (Glu) was selected as the ligand to react with low‐molecular‐weight HA. Fibroblast tests and a 3D skin model were used to investigate the anti‐inflammation efficacy of HA‐Glu.ResultsFor IL‐1α, IL‐6 and TNF‐α, the grafted compound presents stronger inhibition ability versus native HA. Moreover, HA‐Glu could promote the repair of damaged skin by improving the compactness of the stratum corneum and increasing the thickness of the living cell layer.ConclusionThe application of HA‐Glu compound in skin care formulas would be effective to alleviate inflammation‐induced skin symptoms and skin aging.