Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019

Author:

Danpanichkul Pojsakorn12ORCID,Chen Vincent L.3,Chaiyakunapruk Nathorn45ORCID,Auttapracha Thanida6,Kongarin Siwanart6,Ng Cheng Han7ORCID,Duangsonk Kwanjit8,Muthiah Mark D.9ORCID,Sukphutanan Banthoon6,Sim Benedix9,Huang Daniel Q.910ORCID,Seko Yuya11ORCID,Lee Brian P.12,Takahashi Hirokazu13,Noureddin Mazen14,Lazarus Jeffrey V.15161718ORCID,Díaz Luis Antonio10181920ORCID,Arab Juan Pablo19202122,Mellinger Jessica Leigh3,Liangpunsakul Suthat232425,Wijarnpreecha Karn262728ORCID

Affiliation:

1. Department of Internal Medicine Texas Tech University Health Sciences Center Lubbock Texas USA

2. Immunology Unit, Department of Microbiology, Faculty of Medicine Chiang Mai University Chiang Mai Thailand

3. Division of Gastroenterology and Hepatology, Department of Internal Medicine University of Michigan Health System Ann Arbor Michigan USA

4. Department of Pharmacotherapy College of Pharmacy, University of Utah Salt Lake City Utah USA

5. IDEAS Center, Veterans Affairs Salt Lake City Healthcare System Salt Lake City Utah USA

6. Faculty of Medicine Chiang Mai University Chiang Mai Thailand

7. Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan

8. Department of Microbiology, Faculty of Medicine Chiang Mai University Chiang Mai Thailand

9. Division of Gastroenterology and Hepatology, Department of Medicine National University Health System Singapore

10. MASLD Research Center, Division of Gastroenterology University of California at San Diego San Diego California USA

11. Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine, Kawaramachi‐Hirokoji Kyoto Japan

12. Division of Gastroenterology and Liver Diseases University of Southern California Los Angeles California USA

13. Division of Metabolism and Endocrinology, Faculty of Medicine Saga University Saga Japan

14. Houston Research Institute and Houston Methodist Hospital Houston Texas USA

15. CUNY Graduate School of Public Health and Health Policy (CUNY SPH) New York New York USA

16. Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain

17. Barcelona Institute for Global Health (ISGlobal), Hospital Clínic University of Barcelona Barcelona Spain

18. The Global NASH Council Washington DC USA

19. Departamento de Gastroenterologia, Escuela de Medicina Pontificia Universidad Catolica de Chile Santiago Chile

20. Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA Santiago Chile

21. Division of Gastroenterology, Department of Medicine, Schulich School of Medicine Western University & London Health Sciences Centre London Ontario Canada

22. Department of Epidemiology and Biostatistics, Schulich School of Medicine Western University London Ontario Canada

23. Division of Gastroenterology and Hepatology, Department of Medicine Indiana University School of Medicine Indianapolis Indiana USA

24. Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis Indiana USA

25. Roudebush Veterans Administration Medical Center Indianapolis Indiana USA

26. Division of Gastroenterology and Hepatology, Department of Medicine University of Arizona College of Medicine Phoenix Arizona USA

27. Division of Gastroenterology and Hepatology, Department of Internal Medicine Banner University Medical Center Phoenix Arizona USA

28. BIO5 Institute, University of Arizona College of Medicine‐Phoenix Phoenix Arizona USA

Abstract

SummaryBackgrounds and AimsAlcohol use leads to disabilities and deaths worldwide. It not only harms the liver but also causes alcohol use disorder (AUD) and heart disease. Additionally, alcohol consumption contributes to health disparities among different socio‐economic groups.MethodsWe estimated global and regional trends in the burden of AUD, liver disease, and cardiovascular disease from alcohol using the methodology of the Global Burden of Disease study.ResultsIn 2019, the highest disability‐adjusted life years rate per 100,000 population was due to AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated liver disease (ALD) (133.31 [95% UI 112.68–156.17]). The prevalence rate decreased for AUD (APC [annual percentage change] −0.38%) and alcohol‐induced cardiomyopathy (APC −1.85%) but increased for ALD (APC 0.44%) and liver cancer (APC 0.53%). Although the mortality rate for liver cancer from alcohol increased (APC 0.30%), mortality rates from other diseases decreased. Between 2010 and 2019, the burden of alcohol‐associated complications increased in countries with low and low‐middle sociodemographic index (SDI), contributing more significantly to the global burden.ConclusionThe global burden of AUD, liver, and cardiovascular disease has been high and increasing over the past decade, particularly for liver complications. Lower SDI countries are contributing more to this global burden. There is a pressing need for effective strategies to address this escalating burden.

Publisher

Wiley

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