Male pattern hair loss: Can developmental origins explain the pattern?

Author:

Redmond Leah C.1ORCID,Limbu Summik1ORCID,Farjo Bessam2ORCID,Messenger Andrew G.3ORCID,Higgins Claire A.1ORCID

Affiliation:

1. Department of Bioengineering Imperial College London London UK

2. Farjo Hair Institute Manchester UK

3. Department of Dermatology University of Sheffield Sheffield UK

Abstract

AbstractMale pattern hair loss (MPHL), also referred to as male androgenetic alopecia (AGA) is the most common type of non‐scarring progressive hair loss, with 80% of men suffering from this condition in their lifetime. In MPHL, the hair line recedes to a specific part of the scalp which cannot be accurately predicted. Hair is lost from the front, vertex, and the crown, yet temporal and occipital follicles remain. The visual effect of hair loss is due to hair follicle miniaturisation, where terminal hair follicles become dimensionally smaller. Miniaturisation is also characterised by a shortening of the growth phase of the hair cycle (anagen), and a prolongation of the dormant phase (kenogen). Together, these changes result in the production of thinner and shorter hair fibres, referred to as miniaturised or vellus hairs. It remains unclear why miniaturisation occurs in this specific pattern, with frontal follicles being susceptible while occipital follicles remain in a terminal state. One main factor we believe to be at play, which will be discussed in this viewpoint, is the developmental origin of the skin and hair follicle dermis on different regions of the scalp.

Funder

Engineering and Physical Sciences Research Council

Publisher

Wiley

Subject

Dermatology,Molecular Biology,Biochemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Oral Minoxidil Therapy in Hair Loss: Where Do We Stand?;Current Dermatology Reports;2023-11-20

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