Characterization of age‐associated exhausted CD 8 + T cells defined by increased expression of Tim‐3 and PD ‐1-Reference-Cited by-同舟云学术

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Characterization of age‐associated exhausted CD 8 + T cells defined by increased expression of Tim‐3 and PD ‐1

Published:2016-01-10 Issue:2 Volume:15 Page:291-300
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Lee Kyoo‐A¹,Shin Kwang‐Soo¹,Kim Ga‐Young²,Song You Chan¹,Bae Eun‐Ah²,Kim Il‐Kyu¹,Koh Choong‐Hyun¹,Kang Chang‐Yuil¹²

Affiliation:

1. Laboratory of Immunology Research Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University 1 Gwanak‐ro, Gwanak‐gu Seoul 151‐742 Korea

2. Department of Molecular Medicine and Biopharmaceutical Science Graduate School of Convergence Science and Technology Seoul National University 1 Gwanak‐ro, Gwanak‐gu Seoul 151‐742 Korea

Funder

National Research Foundation

Ministry of Health and Welfare

Publisher

Wiley

Subject

Cell Biology,Ageing

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12435

Reference40 articles.

1. Memory T cell homeostasis and senescence during aging

2. Aging is associated with circulating cytokine dysregulation

3. Restoring function in exhausted CD8 T cells during chronic viral infection

4. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

5. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection

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