Genomewide meta‐analysis identifies loci associated with IGF ‐I and IGFBP ‐3 levels with impact on age‐related traits

Author:

Teumer Alexander12,Qi Qibin3,Nethander Maria4,Aschard Hugues5,Bandinelli Stefania6,Beekman Marian7,Berndt Sonja I.8,Bidlingmaier Martin9,Broer Linda1011,Cappola Anne12,Ceda Gian Paolo1314,Chanock Stephen2,Chen Ming‐Huei1516,Chen Tai C.17,Chen Yii‐Der Ida18,Chung Jonathan19,Del Greco Miglianico Fabiola2021,Eriksson Joel22,Ferrucci Luigi23,Friedrich Nele24,Gnewuch Carsten25,Goodarzi Mark O.26,Grarup Niels27,Guo Tingwei19,Hammer Elke2,Hayes Richard B.28,Hicks Andrew A.20,Hofman Albert29,Houwing‐Duistermaat Jeanine J.30,Hu Frank3132,Hunter David J.3133,Husemoen Lise L.34,Isaacs Aaron3536,Jacobs Kevin B.2,Janssen Joop A. M. J. L.37,Jansson John‐Olov38,Jehmlich Nico239,Johnson Simon19,Juul Anders40,Karlsson Magnus41,Kilpelainen Tuomas O.27,Kovacs Peter42,Kraft Peter323343,Li Chao19,Linneberg Allan344445,Liu Yongmei46,Loos Ruth J. F.47,Lorentzon Mattias22,Lu Yingchang47,Maggio Marcello1314,Magi Reedik4849,Meigs James5051,Mellström Dan22,Nauck Matthias3133,Newman Anne B.52,Pollak Michael N.53,Pramstaller Peter P.2021,Prokopenko Inga54,Psaty Bruce M.55,Reincke Martin9,Rimm Eric B.3132,Rotter Jerome I.18,Saint Pierre Aude56,Schurmann Claudia5758,Seshadri Sudha1516,Sjögren Klara22,Slagboom P. Eline7,Strickler Howard D.3,Stumvoll Michael42,Suh Yousin195960,Sun Qi3132,Zhang Cuilin61,Svensson Johan22,Tanaka Toshiko23,Tare Archana19,Tönjes Anke62,Uh Hae‐Won30,van Duijn Cornelia M.3536,Heemst Diana63,Vandenput Liesbeth22,Vasan Ramachandran S.6465,Völker Uwe2,Willems Sara M.35,Ohlsson Claes22,Wallaschofski Henri24,Kaplan Robert C.3, ,

Affiliation:

1. Institute for Community Medicine University Medicine Greifswald 17475 Greifswald Germany

2. Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald 17475 Greifswald Germany

3. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY 10461 USA

4. Bioinformatics Core Facility The Sahlgrenska Academy University of Gothenburg Gothenburg 40530 Sweden

5. Program in Genetic Epidemiology and Statistical Genetics Department of Epidemiology Harvard School of Public Health Boston MA 02115 USA

6. Geriatric Unit Azienda Sanitaria di Firenze (ASF) Florence Italy

7. Molecular Epidemiology Leiden University Medical Center Leiden 2300 RC The Netherlands

8. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD 20892 USA

9. Medizinische Klinik und Poliklinik IV Klinikum der Universitaet Muenchen 80336 Munich Germany

10. Department of Epidemiology Subdivision Genetic Epidemiology Erasmus Medical Center Postbus 2040 3000 CA Rotterdam The Netherlands

11. Department of Internal Medicine Erasmus Medical Center Postbus 20403000 CA Rotterdam The Netherlands

12. Division of Endocrinology, Diabetes, and MetabolismDepartment of Medicine Center for Clinical Epidemiology and Biostatistics University of Pennsylvania School of Medicine Philadelphia PA 19104 USA

13. Section of Geriatrics Department of Clinical and Experimental Medicine University of Parma Parma Italy

14. Geriatric Rehabilitation Department University‐Hospital of Parma Parma Italy

15. Framingham Heart Study Framingham MA 01702 USA

16. Department of Neurology Boston University School of Medicine Boston MA 02118 USA

17. Section of Endocrinology, Diabetes & NutritionBoston University School of Medicine Boston MA 02118 USA

18. Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute at Harbor‐UCLA Medical Center Torrance CA 90502 USA

19. Department of Genetics Albert Einstein College of Medicine Bronx NY 10461 USA

20. Center for Biomedicine European Academy Bozen/Bolzano (EURAC) Bolzano 39100 Italy

21. Affiliated Institute of the University of Lübeck 23562 Lübeck Germany

22. Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg 41345 Gothenburg Sweden

23. Translational Gerontology Branch National Institute on Aging Baltimore MD 21225 USA

24. Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald 17475 Greifswald Germany

25. Institute for Clinical Chemistry and Laboratory Medicine Regensburg University Medical Center D‐93053 Regensburg Germany

26. Division of Endocrinology, Diabetes and Metabolism Department of Medicine Cedars‐Sinai Medical Center Los Angeles CA 90048 USA

27. The Novo Nordisk Foundation Center for Basic Metabolic Research Section of Metabolic Genetics Faculty of Health and Medical Sciences University of Copenhagen 2100 Copenhagen Denmark

28. Division of Epidemiology Department of Population Health New York University School of Medicine New York NY 10016 USA

29. Department of Epidemiology Erasmus University Medical Center Rotterdam 3000 CA The Netherlands

30. Leiden University Medical Center Medical Statistics and Bioinformatics Leiden 2300 RC The Netherlands

31. Department of Nutrition Harvard School of Public Health Boston MA 02115 USA

32. Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA 02115 USA

33. Department of Epidemiology and Statistical Genetics Harvard School of Public Health Boston MA 02115 USA

34. Research Centre for Prevention and Health Capital Region of Denmark Copenhagen DK‐2600 Denmark

35. Genetic Epidemiology Unit Department of Epidemiology Erasmus University Medical Center Rotterdam 3000 CA The Netherland

36. Centre for Medical Systems Biology Leiden 2300 RC The Netherlands

37. Department of Internal Medicine Erasmus University Medical Center Rotterdam 3000 CA The Netherlands

38. Department of Physiology Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg 41345 Gothenburg Sweden

39. Department of Proteomics Helmholtz – Centre for Environmental Research – UFZ 04318 Leipzig Germany

40. Department of Growth and Reproduction Rigshospitalet University of Copenhagen Copenhagen DK‐2100 Denmark

41. Clinical and Molecular Osteoporosis Research Unit Department of Clinical Sciences Lund University 20502 Malmö Sweden

42. IFB Adiposity Diseases University of Leipzig 04103 Leipzig Germany

43. Department of Biostatistics Harvard School of Public Health Boston MA 02115 USA

44. Department of Clinical Experimental Research Glostrup University Hospital Copenhagen DK‐2600 Denmark

45. Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen DK‐2200 Denmark

46. Division of Public Health Sciences Department of Epidemiology and Prevention Wake Forest School of Medicine Winston‐Salem NC 27157 USA

47. The Genetics of Obesity and Related Metabolic Traits Program The Charles Bronfman Institute for Personalized Medicine The Icahn School of Medicine at Mount Sinai New York NY 10029 USA

48. Estonian Genome Center University of Tartu Tartu Estonia

49. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK

50. General Medicine Division Department of Medicine Massachusetts General Hospital Boston MA 02114 USA

51. Division of General Medicine Harvard Medical School Boston MA 02115 USA

52. Department of Epidemiology School of Public Health University of Pittsburgh Pittsburgh PA 15261 USA

53. Departments of Experimental Medicine and Oncology McGill University Montréal Québec Canada H3A 0G4

54. Department of Genomics of Common Disease School of Public Health Imperial College London London W12ONN UK

55. Departments of Epidemiology, Medicine and Health Services University of Washington Seattle WA 98101 USA

56. INSERM U1078 Brest France

57. The Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA

58. The Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY 10029 USA

59. Department of Medicine Albert Einstein College of Medicine Bronx NY 10461 USA

60. Institute of Aging Research Guangdong Medical College Dongguan China

61. Epidemiology Branch Division of Epidemiology, Statistics and Prevention Research Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health 6100 Executive Blvd Rockville MD 20852 USA

62. Medical Department University of Leipzig 04103 Leipzig Germany

63. Gerontology and Geriatrics Leiden University Medical Center Leiden 2300 RC The Netherlands

64. Boston University and National Heart Lung & Blood Institute's Framingham Heart Study Framingham MA 01702 USA

65. Preventive Medicine & Epidemiology Section Boston University School of Medicine Boston MA 02118 USA

Publisher

Wiley

Subject

Cell Biology,Aging

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