Interleukin‐21 administration to aged mice rejuvenates their peripheral T‐cell pool by triggering de novo thymopoiesis
Author:
Affiliation:
1. Department of Pharmacology Université de Montréal Montréal QC H3C 1J7 Canada
2. Université Paris‐Sud, Faculté de Pharmacie 5 rue J.B. Clément 92296 Châtenay‐Malabry Cedex France
Funder
Cancer Research Society
Publisher
Wiley
Subject
Cell Biology,Ageing
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12440
Reference45 articles.
1. Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice
2. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
3. Recent Thymic Emigrants and Mature Naive T Cells Exhibit Differential DNA Methylation at Key Cytokine Loci
4. Thymus involution and regeneration: two sides of the same coin? Nature reviews;Boehm T;Immunology,2013
5. Continued maturation of thymic emigrants in the periphery
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