Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital-Reference-Cited by-同舟云学术

Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital

Published:2023-12-22 Issue:2 Volume:44 Page:286-292
ISSN:1478-3223
Container-title:Liver International
language:en
Short-container-title:Liver International

Author:

Pocurull Anna¹²,Moreta Maria José¹,Heitman David¹,Olivas Ignasi¹²,Collazos Cristina¹,Canga Elia¹,Sáez‐Peñataro Joaquin³,Andrade Raul J.²⁴^ORCID,Lucena M. Isabel²⁴^ORCID,Mariño Zoe¹²^ORCID,Díaz Alba²⁵,Lens Sabela¹²^ORCID,Londoño María Carlota¹²^ORCID,Forns Xavier¹²^ORCID

Affiliation:

1. Liver Unit, Hospital Clínic University of Barcelona, IDIBAPS Barcelona Spain

2. Centro de Investigación en Red de Hepatología y Gastroenterología, CIBERehd Madrid Spain

3. Clinical Pharmacology Department, Medicine Department, Pharmacovigilance Program, Hospital Clínic University of Barcelona, IDIBAPS Barcelona Spain

4. Unidad de Gestión Clínica de Enfermedades Digestivas, Instituto de Investigación Biomédica de Málaga‐IBIMA Plataforma BIONAND, Hospital Universitario Virgen de la Victoria Universidad de Málaga Málaga Spain

5. Pathology Department, Hospital Clínic. IDIBAPS University of Barcelona Barcelona Spain

Abstract

AbstractDrug‐induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check‐point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.

Publisher

Wiley

Subject

Hepatology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/liv.15821

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